| Wednesday, September 16 |
| 08:00-9:00 |
Registration |
| 09:00-09:15 |
Opening |
| Historical Session |
| Chair: Helmut Cölfen |
| 09:15-09:45 |
Lars-Olof Sundelöf: Memories of Svedberg and Svedberg’s
role for the development of physical chemistry and biomedicine |
| 09:45-10:10 |
Mike Creeth: From Oil-turbine to Model E - Early Days in in Retrospect |
| 10:10-10:40 |
Tom Laue: The Development of the Model E |
| 10:40-11:05 |
Georges Pavlov: Analytical Ultracentrifugation in the Former Soviet Union. The MOM ultracentrifuges |
| 11:05-11:20 |
Break |
| 11:20-11:50 |
Arthur Rowe: Down the nanometer scale: securing the foundations of hydrodynamics |
| 11:50-12:20 |
Victor Bloomfield: Development of Hydrodynamic Modelling of Complex Biopolymers |
| 12:20-12:50 |
Curt Ekström: The Svedberg Laboratory - 60 years of accelerator-based
basic research and applications at Uppsala University |
| |
| 12:50-13:50 |
Lunch |
| |
| 13:50-15:00 |
Poster Session #1 |
| 15:00-15:20 |
Conference photo (at entrance 3D) |
| 15:20 |
Visit to The Svedberg’s Ultracentrifuge Museum and to
The Svedberg Laboratory |
| 18:20 |
Reception at the Uppsala University Main Building |
| Thursday, September 17 |
| Session 1: Shape and conformational analysis |
| Chairs: Olwyn Byron and Arthur Rowe |
| 09:00-09:20 |
Stephen E. Harding: Advances in conformational analysis in
heterogeneous systems |
| 09:20-09:40 |
J. Garcia de la Torre, A. Ortega, D. Amoros, J.G. Hernandez Cifre:
Methods and tools for the prediction of hydrodynamic coefficient and other
solution properties of flexible macromolecules and nanoparticles |
| 09:40-10:00 |
Emre Brookes, Borries Demeler, Mattia Rocco: Developments in the
US-SOMO bead modeling suite: New features in the direct residue-to-bead method,
improved grid routines, and simulation of SAXS data |
| 10:00-10:20 |
Stephen J. Perkins, Alexandra Bonner: Constrained solution scattering
and sedimentation coefficient modelling of human IgA antibodies reveal novel
biological insights |
| 10:20-10:50 |
Break |
| Session 2: To Be Announced |
| 10:50-12:30 |
Selected short presentations from posters |
| Chairs: Geoff Howlett and Helmut Cölfen |
| |
| 12:30-13:30 |
Lunch |
| |
| 13:30-15:00 |
Poster session #3 |
| Session 3: Complex biological systems |
| Chairs: Christine Ebel and Karen Fleming |
| 15:00-15:20 |
Christine Ebel: Characterisation of Membrane Proteins In
Solution |
| 15:20-15:40 |
Alexandra Ebie Tan, Nancy K. Burgess, Karen G. Fleming:
Sedimentation Velocity Analysis of Membrane Protein Folding |
| 15:40-16:00 |
Geoff Howlett, Shuo Yang, Tim Ryan: Sedimentation Velocity
Analysis of Amyloid Fibril Formation |
| 16:00-16:20 |
Nikola Wenta, Holger Strauss, Stephanie Meyer, Uwe Vinkemeier:
Tyrosine phosphorylation regulates the partitioning of STAT1 between
different dimer conformations |
| Session 4: Methods & Tools: data
evaluation, alternative techniques |
| Chairs: Tom Laue and Borries Demeler |
| 17:10-17:30 |
Walter Stafford, David Hayes: Real Time, Online Time
Derivative Sedimentation Velocity Analysis with SEDVIEW |
| 17:30-17:45 |
Vikas Mittal, Antje Voelkel, Helmut Cölfen:Analytical
Ultracentrifugation of Inorganic Nanoparticles: Comparison of
Different Analysis Methods |
| 17:45-18:05 |
Igor Perevyazko, Antje Vollrath, Christian Pietsch, Stephanie
Hornig, Georges M. Pavlov, Ulrich S. Schubert: Comparison of
analytical ultracentrifugation, dynamic light scattering and scanning
electron microscopy for the size determination of poly(methyl
methacrylate) nanoparticles |
| 18:05-18:20 |
Susumu Uchiyama, Masanori Noda, Sachihiro Matsunaga, Adam McKay,
Carol Robinson, Yuji Kobayashi, Kiichi Fukui: Protein-Protein
Interactions Observed by Different Biophysical Methods |
| 19:30 |
Conference Dinner at the Orangery of the Linnaeus Garden |
| Friday, September 18 |
| Session 5: Colloids and synthetic macromolecules |
| Chairs: Christine Wandrey and Wendel Wohlleben |
| 09:00-09:15 |
O.V. Okatova, N.N. Ulyanova, A.V.Mikhailova, I.I.Gavrilova,
E.F.Panarin, G.M.Pavlov: Sedimentation, Translational Diffusion
and Viscosity of Poly-N-methyl-N-vinylacetamide in aqueous solutions |
| 09:15-09:30 |
Engin Karabudak, Claudia Backes, Andreas Hirsch, Helmut Cölfen,
Wendel Wohlleben: Carbon Nanotube – ligand interactions
investigated by a Multiwavelength UV-Vis detector |
| 09:30-09:45 |
Dominique M.E. Thies-Weesie, Karel L.Planken, Mircea Rasa, Albert P.
Philipse: Macroscopic electric field in the sedimentation profiles
of charged colloids and proteins |
| 09:45-10:05 |
Torsten Detloff, Dietmar Lerche: Separation of Concentrated
Dispersions in a Multisample Analytical Centrifuge: Experiments and
Theoretical Models |
| Session 6: Sedimentation analysis of
reversibly interacting macromolecules |
| Chairs: Jack Correia and Walter Stafford |
| 11:00-11:20 |
Peter Schuck: The effective particle for the sedimentation
of rapidly interacting macromolecules |
| 11:20-11:40 |
Joachim Behlke, Otto Ristau: Analysis of competitive ligand
binding by analytical ultracentrifugation |
| 11:40-11:55 |
Borries Demeler, Emre Brookes, Weiming Cao: Determination of
kinetic parameters for self-associating systems displaying slow
kinetics using UltraScan |
| 11:55-12:10 |
Arthur J Rowe: Evaluation of the information content of
sedimentation equilibrium data |
| 12:10-12:30 |
P. Holland Alday, John J. Correia: The Use of AUC to Study
the Mode of Action of the Anti-mitotic Drug Eribulin |
| |
| 12:30-13:30 |
Lunch |
| |
| Session 7: Analysis of protein function
using ultracentrifugation techniques |
| Chairs: Mattia Rocco and Steve Perkins |
| 13:30-13:45 |
Peter A. Lemaire, Jennifer VanOudenhove, C. Jason Wong, Katherine
Launer-Felty, Eric Anderson, Jeffrey W. Lary, Laurie A. Heinicke,
Graeme L. Conn, Philip C. Bevilacqua, Susan Krueger, James L. Cole:
Mechanism of activation of the antiviral kinase PKR |
| 13:45-14:00 |
Dmitry B. Veprintsev: Modulation of the oligomerization state
of the tumour suppressor p53 by partner proteins |
| 14:00-14:20 |
Tom Laue: Proximity energies: a framework for understanding
high concentration fluids |
| 14:20-14:35 |
Natalie Naue, Roman Fedorov, Andreas Pich, Peter Schmieder, Ute
Curth: Protein-protein interactions at the DNA replication
fork of E.coli |
| 14:35-14:50 |
Ariadna Martos, Rubén Ahijado, Pilar López-Navajas,
Mercedes Jiménez, Carlos Alfonso, Francisco Monroy, Marisela
Vélez, Miguel Vicente, Allen P. Minton, Germán
Rivas: Biophysical analysis of bacterial cell division proto-ring
protein interactions |
| 14:50-15:05 |
Concluding remarks |
